科研情况: ◉ 近5年科研项目: 1、长沙市杰出青年科技人才培养计划,kq2506009,2025/01-2027/12,在研,主持。 2、湖南省自然科学基金面上项目,2025JJ50061,染料拓扑组装放大体系的构建及高保真细胞荧光成像,2025/01-2027/12,在研,主持。 3、国家自然科学基金青年基金项目,21804012,“胞浆蛋白辅助荧光放大”高灵敏检测及荧光成像成纤维细胞活化蛋白,2019/01-2021/12,已结题,主持。 4、湖南省自然科学基金青年基金项目,2019JJ50634,金属离子辅助荧光放大纳米探针构建及其在炎症性肠病成像中的应用,2019/01-2021/12,已结题,主持。 5、湖南省教育厅优秀青年基金项目,23B0308,ATP辅助信号放大荧光成像抑郁症相关单胺氧化酶A,2023/10-2025/10,已结题,主持。 6、长沙市自然科学基金,kq2208216,ATP多价结合驱动信号放大策略的构建及肝硬化成像分析,2023/01-2024/12,已结题,主持。 7、区域遗传性出生缺陷防控研究湖南省重点实验室开放基金重点项目,HPKL2023009,类酶催化荧光放大体系的构建及胚胎Zn2+成像应用研究,2023/10-2025/10,已结题,主持。 8、化学生物传感与计量学国家重点实验室开放基金项目,2021018,基于H-聚集的零背景荧光信号放大纳米探针的构建及胚胎多硫化氢成像研究,2022/04-2024/04,已结题,主持。 ◉ 近3年科研论文: (1)Yibo Zhou, Yuping Wang, Aoshuang Xu, Qiuhong Mo, Xiaowen Liu, Min Liu, Xiaohan Zhang, Juewen Liu, Zhihe Qing. Physically Masked Nanoflares for Accurate Biological Applications by Blocking Nucleases. Angew. Chem. Int. Ed., 2025, e13763. (A1, IF=17) (2)Yibo Zhou, Zhengxuan Gu, Changhui Liu, Sheng Yang*, Xiaofei Ma, Qiaoshu Chen, Yanli Lei, Ke Quan, Juewen Liu, Zhihe Qing*, Ronghua Yang*. A Polymeric Nanobeacon for Revealing Hydrogen Polysulfides Fluctuation during Fertilization and Embryonic Development. Angew. Chem. Int. Ed., 2022, 61, e202114504. (A1, IF=17, VIP论文) (3)Xiaowen Liu, Shuanghong Sun, Xinchao Xia, Huiqiu Shi, Le Yang, Zenghui Mao, Xianjin Xiao, Yibo Zhou*, Zhihe Qing*. Uncovering the Fluctuation of Peroxynitrite during Early Embryonic Development Using an Integrative Nanobeacon. Analytical Chemistry, 2025, 97, 6192-6200. (A1, IF=7.4) (4)Le Yang, Xinchao Xia, Fan Li, Qiuhong Mo, Pin Shang, Junbin Li, Yi Li, Yibo Zhou*, Zhihe Qing*. Fluorescent visualization of endoplasmic reticulum stress induced by microplastic pollution via surge of intracellular reactive oxygen species. Analytica Chimica Acta, 2025, 1380, 344777. (A2, IF=6.2) (5)Qiuhong Mo, Jun Zhang, Pin Shang, Yibo Zhou*, Zhihe Qing. Research Progress on Delivery and Detection of Hydrogen Selenide in Vivo. Acta Chim. Sinica, 2025, 83, 10.6023/A25110365. (A2) (6)Yibo Zhou*, Jun Zhang, Shuanghong Sun, Weiju Chen, Yuping Wang, Huiqiu Shi, Ronghua Yang*, Zhihe Qing*. Amplified biosensor powered by endogenous molecules for intracellular fluorescence imaging. Analytical Chemistry, 2024, 96, 20, 8078-8090. (A1, IF=7.4) (7)Yibo Zhou*, Huiqiu Shi, Xinchao Xia, Sheng Yang*, Junbin Li, Zhihe Qing, Jing Zheng, and Ronghua Yang. Integration of Hybridization Chain Reaction and Protein-Binding Amplification for Long-Term Imaging of Intracellular mRNA: Avoiding Signal Fluctuation. Analytical Chemistry, 2024, 96, 11061-11067. (A1, IF=7.4) (8)Ni Zeng, Xiuhong Guan, Xiaowen Liu, Huiqiu Shi, Nan Li, Ruimeng Yang, Yibo Zhou*. Fibroblast activation protein-sensitive polymeric nanobeacon for early diagnosis of renal fibrosis. Biosensors and Bioelectronics, 2024, 253,116144. (A1, IF=10.5) (9)Yibo Zhou*, Shan Hu, Hongwen Liu, Xinyue Xiao, Weiju Chen, Sheng Yang, Huiqiu Shi, Zhenxuan Gu, Junbin Li, Ronghua Yang*, Zhihe Qing*. Activity-Independent Enzyme-Powered Amplification for Improving Signal Stability and Fidelity in Biosensing. Chemical & Biomedical Imaging, 2024, 2, 4, 304-312 (A1, , IF=5.7封面论文) (10)Junbin Li, Na Wang, Mengyi Xiong*, Min Dai, Cheng Xie, Qianqian Wang, Ke Quan, Yibo Zhou*, Zhihe Qing*. A Reaction-Based Ratiometric Bioluminescent Platform for Point-of-Care and Quantitative Detection Using a Smartphone, Analytical Chemistry, 2023, 95, 18, 7142-7149. (A1, IF=7.4) (11)Yibo Zhou, Xiaofei Ma, Shan Hu, Sheng Yang, Jingru Guo, Junbin Li, Yue-Fei Zhang, Juewen Liu, Zhihe Qing*, Ronghua Yang*. Rigidity-Dependent Emission: Inspired Selection of an ATP-Specific Polyvalent Hydrogen Binding-Lighted Fluorophore for Intracellular Amplified Imaging, Analytical Chemistry, 2023, 95, 21, 8318-8324. (A1, IF=7.4) (12)Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li*, Yibo Zhou*. Monitoring H2S fluctuation during autophagic fusion of lysosomes and mitochondria using a lysosome-targeting fluorogenic probe, Analytica Chimica Acta, 2023, 1265, 341356. (A1, IF=6.2) (13)Huihong Liu, Xianqing Zeng, Honghui Yin, Jing Chen, Wenzhi Xie, Guoqiang Zhou, Guojiang Mao, Yibo Zhou*, Sheng Yang*. A pH-switchable azo-based fluorescence reporter for lysosome-confined visualization of hypoxia status. Sensors & Actuators: B. Chemical., 2023, 381, 133431. (A1, IF=7.7) ◉科研奖励: 1. 湖南省自然科学二等奖 2. 长沙市杰出青年培养计划 3. 湖南省普通高校青年骨干教师 4. 国产a视频免费观看不卡“湖湘学者”青年英才 5. 湖南省化学化工学会第十八届青年化学化工奖 6. 湖南省优秀硕士论文指导教师 ◉ 近5年申请专利: 1. 周怡波,尹柯仪,杨荣华。一种能长时间成像FAP的生物发光探针及其应用, 2022-9-13, 中国, ZL2020 1 0860240.4 2. 周怡波,胡山,杨荣华。一种响应ATP的荧光染料及其制备方法和应用, 2024-1-3, 中国, ZL 2022 1 1374678.7 3. 周怡波,胡山,肖新月,卿志和。一种响应羧酸酯酶荧光染料及其制备方法及应用,2023-12-15, 中国, 202311730996.7 |